====== Project Overviews ======

===== TRR265 : Losing and Regaining Control over Drug Intake =====

^ Nummer ^ Kürzel ^ Name                                        ^ Standort ^ Principal Investigators ^
| 10101  | S01    | Central recruitment, imaging and biobanking | Mannheim\\ Berlin\\ Dresden | Derik Hermann\\ Henrik Walter\\ Michael Marxen\\ Marcella Rietschel|
| 10102  | S02    | Mobile infrastructure for daily life research |Karlsruhe\\ Heidelberg\\ Mannheim|Ulrich Ebner-Priemer\\ Jan Stallkamp\\ Andreas Meyer-Lindenberg|
| 10103	 | INF    | Information infrastructure |Dresden| Wolfgang E. Nagel\\ Michael Smolka|
| 10104  | Z      | Central Tasks of the Collaborative Research Center|Berlin|Andreas Heinz|
| 10111  | A01    | Longitudinal monitoring of triggers and modifying factors in human addiction|Potsdam\\ Mannheim\\ Berlin|Michael Rapp\\ Tobias Banaschewski\\ Andreas Heinz|
| 10112  | A02    | Longitudinal monitoring of cognitive control as a modifying factor of drinking behavior|Dresden|Lorenz Deserno\\ Michael Smolka|
| 10113  | A03    | Stress-related predictor profiles for craving and relapse in human addiction|Mannheim\\  Heidelberg\\ Dresden|Falk Kiefer\\ Jan Stallkamp\\ Clemens Kirschbaum|
| 10114  | A04    | Intense characterization of triggers, modifying factors and mechanisms at course transition points in human addiction|Mannheim\\ Karlsruhe\\ Berlin|Heike Tost\\ Ulrich Ebner-Priemer\\ Christine Heim|
| 10115  | A05    | Intensive behavioral monitoring and dynamical state transitions in animal models of addiction|Mannheim|Hamid Noori\\ Rainer Spanagel|
| 10116  | A06    | AI-based predictive neuro-behavioral modeling of individual trajectories in addiction|Mannheim| Daniel Durstewitz\\ Georgia Koppe|
| 10117 | A07    | Deep Learning for identifying subtypes in addiction based on structural MRI data|Berlin| Kerstin Ritter|
| 10118 | A08    | Effekte longitudinaler Sexualhormonveränderungen auf Verlust und Wiedererlangen von Kontrolle über den Alkoholkonsum: Prädiktion, Mechanismen und Behandlungstargets. |Berlin| Bernd Lenz|
| 10121  | B01    | Moderators of habitual versus goal-directed decision making in human addiction|Berlin\\ Dresden	| Florian Schlagenhauf\\ Tanja Endrass|
| 10122  | B02    | Habit formation and its relevance in alcohol addiction|Mannheim|Anita Hansson\\ Wolfgang Sommer|
| 10123  | B03    | Cue effects in human addiction: Pavlovian to instrumental transfer|Berlin\\ Dresden|Andreas Heinz\\ Maximilian Pilhatsch|
| 10124  | B04    | Cue effects and targeted neuromodulation in animal models and human addiction|Berlin|Christine Winter\\ Josef Priller|
| 10125  | B05    | Cognitive control of negative affect and craving for drug and alternative rewards across substance use disorders|Berlin|Henrik Walter\\ Georg Winterer|
| 10126  | B06    | Probing reward function during the addiction cycle by intracranial self-stimulation: the role of monoamines and alternative rewards|Mannheim|Rainer Spanagel|
| 10127  | B07    | Addiction-related changes in automatic S-R associations and their effects on cognitive control|Dresden|Christian Beste\\ Ann-Kathrin Stock|
| 10128  | B08    | Aversion discounting in behavioral control in animal models and human addiction|Mannheim|Wolfgang Sommer\\ Georgia Koppe\\ Peter Kirsch|
| 10129  | B09    | Computational modelling of impaired control in addiction|Dresden|Michael Smolka\\ Stefan Kiebel|
| 10131  | C01    | Modification of the imbalance between goal-directed and habitual behavior in human addiction|Mannheim|Sabine Vollstädt-Klein\\ Herta Flor|
| 10132  | C02    | Modification of Pavlovian and instrumental learning in human addiction|Berlin|Nina Romanczuk-Seiferth\\ Anne Beck|
| 10133  | C03    | Modification of alternative reward cue reactivity and cognitive control through physical activity in human nicotine use disorder|Berlin|Felix Bermpohl\\ Andreas Ströhle|
| 10134  | C04    | Modification of cue reactivity by neurofeedback and mindfulness-based intervention in human addiction|Mannheim|Peter Kirsch\\ Falk Kiefer|
| 10135  | C05    | Towards causal insights into contextual influences on substance use: Incorporating momentary interventions into everyday life|Berlin\\ Mannheim|Shuyan Liu\\ Markus Reichert|
| 10223  | B03 2. FP | Cue effects in human addiction: Pavlovian to instrumental transfer|Berlin\\ Dresden|Andreas Heinz\\ Maximilian Pilhatsch |Berlin\\ Mannheim|Shuyan Liu\\ Markus Reichert|

===== TRR369 : Degeneration of Bone Induced by Inflammation (DIONE) =====

^ Nummer ^ Kürzel ^ Name                                          ^ Standort         ^ Principal Investigators ^
| 12101   | Z01    | Comprehensive characterization of patients with inflammatory bone disease with serological profiling and imaging | Nürnberg\\ Dresden\\ | Georg Schett\\ Lorenz C. Hofbauer\\ Elena Tsourdi\\ Peter Mirtschink|
| 12102   | Z02    | Administrative tasks of CRC/TRR369 | Nürnberg| Aline Bozec|
| 12103	 | INF    | Information infrastructure |Dresden| Ralph Müller-Pfefferkorn\\ Martina Rauner|
| 12111   | A01    | Regulatory mechanisms linking chronic gut inflammation and bone loss | Nürnberg\\ Dresden | Mario M. Zaiss\\ Ben Wielockx|
| 12112   | A02    | Inflammation-induced intestinal epithelial regulated necrosis as a novel modulator of bone resorption | Nürnberg| Aline Bozec\\ Claudia Günther|
| 12113   | A03    | Consequences of gut-imprinted immune cell trafficking for bone homeostasis | Nürnberg\\ Dresden | Sebastian Zundler\\ Juliane Salbach-Hirsch| 
| 12114   | A04    | Cross-talk between skin and joints impairs bone homeostasis in psoriatic arthritis | Nürnberg\\ Dresden | Andreas Ramming\\ Claudia Günther|
| 12115   | A05    | The role of the transferrin receptor 2 in infection and inflammatory induced bone loss | Dresden\\ Nürnberg | Ulrike Baschant\\ Carina Scholtysek|
| 12116   | A06    | Iron metabolism during inflammation- derived bone loss – investigating the impact of iron on synovial fibroblast metabolism and function | Dresden | Maria G. Ledesma Colunga\\ Tiago C. Alves|
| 12121   | B01    | Defining the regulation and role of bone marrow adipocytes during inflammatory bone loss | Dresden | Martina Rauner|
| 12122   | B02    | The impact of neutrophils and neutrophil-derived myeloperoxidase on osteoclasts and inflammatory bone loss | Nürnberg | Ulrike Steffen |
| 12123   | B03    | Exploring the protective role of eosinophils in bone loss caused by inflammatory arthritis | Nürnberg | Darja Andreev |
| 12124   | B04    | Histocytometric and molecular assessment of the inflammatory osteoclastogenic niche in situ | Nürnberg | Lina Gölz\\ Stefan Uderhardt|
| 12125   | B05    | Arginine supplementation as new therapeutic option against inflammatory bone loss |Nürnberg | Aline Bozec\\ Ulrike Schleicher|
| 12126   | B06    | Genetically-driven cell-specific activation of glucocorticoids and GR as a therapeutic tool in inflammatory arthritis | Ulm\\ Dresden| Jan Tuckermann\\ Ulrike Baschant|
| 12131   | C01    | Regulation of autoantibody-induced bone inflammation and osteoclastogenesis via the Ctype lectin receptor Mincle |Nürnberg | Falk Nimmerjahn|
| 12132   | C02    | Role for the c-type lectin receptor Dectin-1 (Clec7a) in inflammatory periodontal disease |Nürnberg | Bettina Grötsch\\ Manuel Weber|
| 12133   | C03    | Innate immune training-mediated regulation of osteoclasts and inflammatory bone loss |Dresden| Triantafyllos Chavakis\\ Lydia Kalafati|
| 12134   | C04    | Differentiation and fate of osteoclasts during health and disease |Dortmund\\ Nürnberg | Anika Grüneboom\\ Gerhard Krönke|
| 12135   | C05    | Defining the role of osteomorphs in inflammatory bone loss |Dresden| Peter Mirtschink\\ Lorenz C. Hofbauer|
| 12136   | C06    | Role of type I interferon in inflammatory bone disease |Nürnberg\\ Dresden | Georg Schett\\ Min Ae Lee-Kirsch|

===== TRR393 : Trajectories of Affective Disorders =====

^ Nummer ^ Kürzel ^ Name                                                                         ^ Standort         ^ Principal Investigators ^
| 11101  | S01    | Mobile infrastructure      | KIT    | Ulrich Ebner-Priemer |
| 11102  | S02    | Longitudinal intermittent sampling  | Marburg\\ Dresden | Nina Alexander\\ Andrea Pfennig |
| 11103  | S03    | Machine learning development and infrastructure platform | Münster\\ Marburg| Tim Hahn\\ Hamidreza Jamalabadi |
| 11111  | A01    | Longitudinal monitoring in affective disorders                               | KIT\\ Münster    | Ulrich Ebner-Priemer\\  Tim Hahn |
| 11112  | A02    | Longitudinal trajectories of brain changes as mediators of course of illness | Dresden\\ Münster| Eva Mennigen\\ Udo Dannlowski |
| 11113  | A03    | Dissecting the contribution of immune cell activation dependent neuronal connectivity changes to disease trajectories in major depression | Münster\\ Bonn | Michael Ziller\\ Andreas Forstner |
| 11114  | A04    | Brain network characterization of symptom changes using intense sampling | Münster\\ Marburg|Katharina Koch\\ Igor Nenadić |
| 11115  | A05    | Molecular and immunological characterization of symptom changes and course of illness using intense sampling | Münster\\ Dresden| Judith Alferink\\ Carmine Pariante |
| 11116  | A06    | Intense sampling for symptom changes on the trajectory from bipolar high risk to bipolar disorder | Dresden |Julia Martini\\ Andrea Pfennig |
| 11121  | B01    | Emotion perception, emotion regulation variability and flexibility modulate the effect of stressful life events on the course of illness in affective disorders | Marburg\\ Dresden|Andreas Jansen\\ Stefan Ehrlich|
| 11122  | B02    | Characterization of life event-triggered inflection signals and emotion regulation in a mouse model | Münster\\ Dresden| Kay Jüngling\\ Nadine Bernhardt |
| 11123  | B03    | The mechanistic role of expectation in the development of symptom changes in patients with MDD | Marburg | Benjamin Straube\\ Hamidreza Jamalabadi|
| 11124  | B04    | Identifying inflection signals through continuous long-term monitoring of changes in affect and expectations in genetic rat models for affective disorders | Marburg | Markus Wöhr\\ Carsten Culmsee |
| 11125  | B05    | Social interaction predictors of symptom change in major depression | Marburg\\ Dresden| Nina Alexander\\ Philipp Kanske |
| 11126  | B06    | Brain activity correlates of socio-affective communication and cognition under genetic risk modulated through stressful life events |Dresden\\ Marburg |Nadine Bernhardt\\ Markus Wöhr|
| 11127  | B07    | Linking cognitive-behavioural rhythms to brain oscillations, cognition and disease trajectories | Münster\\ \\ Dresden | Ida Wessing\\  Joachim Groß\\ Philipp Ritter |
| 11128  | B08    | Impact of chronobiological modulation on sleep/EEG rhythm and immune-metabolic parameters | Marburg\\ Münster | Carsten Culmsee\\ Kay Juengling|
| 11131  | C01    | Emotion regulation and depressive course of illness | Dresden\\ Marburg|Katharina Förster\\ Stefan G. Hofmann |
| 11132  | C02    | Expectation violation and reward sensitivity in psychological interventions modifying course of illness in acute depression | Marburg | Winfried Rief\\ Igor Nenadić |
| 11133  | C03    | Social interaction-based mental training in major depression | Dresden | Philipp Kanske |
| 11134  | C04    | Cortical synaptic strength and behavioural rhythms in bipolar depression | Dresden\\ \\ Münster |Philipp Ritter\\ Allan Young\\ Joachim Groß|